BibTeX:

@article{IJIRSTV1I6045,
     title={In-silico docking studies on insecticide resistance acetylcholinesterase (AChE) gene in Aphis gossypii and Bemisia tabaci},
     author={Ganesh G Tilve, Dr. Gurumurthy , Miss Jyothi U Bhatkal and Miss Siridevi G B},
     journal={International Journal for Innovative Research in Science & Technology},
     volume={1},
     number={6},
     pages={87--92},
     year={},
     url={http://www.ijirst.org/articles/IJIRSTV1I6045.pdf},
     publisher={IJIRST (International Journal for Innovative Research in Science & Technology)},
}

An insect may employ behavioral strategies or have particular physiological characteristics or modified biochemical mechanisms that enable it to survive in the environment which would be toxic to the normal population, which is otherwise called insecticide resistance phenomenon. Mechanisms of insecticide resistance found in insects may include three general categories viz, modified behavioral mechanisms, physiological mechanisms and biochemical mechanisms. In order to understand the insecticide resistance mechanism specially using in silico bioinformatics tools and techniques, we focused towards the third category biochemical mechanism of insecticide resistance. Ache (Acetylcholinesterase) is one among the enzymes/proteins targeted by most of insecticides, as a result reduced sensitivity of AChE to organophosphates and carbamates which act by inhibiting AChE, a most common type of alteration of target site which lead to resistance. Here this work considered Aphis gossypii and Bemisia tabaci insect's AChE genes and performed the in silico docking with the eight insecticide compounds and tracked two most efficiently docked compounds i.e., tetrachlorvinphos and dicrotophos based on binding affinity to the receptor.

Acetylcholinesterase gene, Aphis gossypii, Bemisia tabaci, organophosphate insecticides, in-silico docking